Combinatorial Targeting by MicroRNAs Co-ordinates Post-transcriptional Control of EMT
نویسندگان
چکیده
منابع مشابه
Transcriptional Control of Gene Expression by MicroRNAs
MicroRNAs (miRNAs) control gene expression in animals and plants. Like another class of small RNAs, siRNAs, they affect gene expression posttranscriptionally. While siRNAs in addition act in transcriptional gene silencing, a role of miRNAs in transcriptional regulation has been less clear. We show here that in moss Physcomitrella patens mutants without a DICER-LIKE1b gene, maturation of miRNAs ...
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Mammalian gene expression patterns change profoundly in response to low oxygen levels. These changes in gene expression programs are strongly influenced by post-transcriptional mechanisms mediated by mRNA-binding factors: RNA-binding proteins (RBPs) and microRNAs (miRNAs). Here, we review the RBPs and miRNAs that modulate mRNA turnover and translation in response to hypoxic challenge. RBPs such...
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ژورنال
عنوان ژورنال: Cell Systems
سال: 2018
ISSN: 2405-4712
DOI: 10.1016/j.cels.2018.05.019